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Dokumenttyp:
journal article 
Autor(en):
Schreck, C; Bock, F; Grziwok, S; Oostendorp, RAJ; Istvanffy, R 
Titel:
Regulation of hematopoiesis by activators and inhibitors of Wnt signaling from the niche 
Abstract:
Hematopoietic stem cells (HSCs) are a rare population of somatic stem cells that have the ability to regenerate the entire mature blood system in a hierarchical way for the duration of an adult life. Adult HSCs reside in the bone marrow niche. Different niche cell types and molecules regulate the balance of HSC dormancy and activation as well as HSC behavior in both normal and malignant hematopoiesis. Here, we describe the interplay of HSCs and their niche, in particular the involvement of the W...    »
 
Zeitschriftentitel:
Ann N Y Acad Sci 
Jahr:
2014 
Band / Volume:
1310 
Seitenangaben Beitrag:
32-43 
Sprache:
eng 
Print-ISSN:
0077-8923 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik