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Document type:
journal article 
Author(s):
Schreck, C; Bock, F; Grziwok, S; Oostendorp, RAJ; Istvanffy, R 
Title:
Regulation of hematopoiesis by activators and inhibitors of Wnt signaling from the niche 
Abstract:
Hematopoietic stem cells (HSCs) are a rare population of somatic stem cells that have the ability to regenerate the entire mature blood system in a hierarchical way for the duration of an adult life. Adult HSCs reside in the bone marrow niche. Different niche cell types and molecules regulate the balance of HSC dormancy and activation as well as HSC behavior in both normal and malignant hematopoiesis. Here, we describe the interplay of HSCs and their niche, in particular the involvement of the W...    »
 
Journal title abbreviation:
Ann N Y Acad Sci 
Year:
2014 
Journal volume:
1310 
Pages contribution:
32-43 
Language:
eng 
Print-ISSN:
0077-8923 
TUM Institution:
III. Medizinische Klinik und Poliklinik