Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Spoerl, Silvia; Mathew, Nimitha R; Bscheider, Michael; Schmitt-Graeff, Annette; Chen, Sophia; Mueller, Tony; Verbeek, Mareike; Fischer, Julius; Otten, Vera; Schmickl, Martina; Maas-Bauer, Kristina; Finke, Jürgen; Peschel, Christian; Duyster, Justus; Poeck, Hendrik; Zeiser, Robert; von Bubnoff, Nikolas 
Titel:
Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease. 
Abstract:
Graft-versus-host-disease (GVHD) is a severe complication of allogeneic hematopoietic cell transplantation (allo-HCT) characterized by the production of high levels of proinflammatory cytokines. Activated Janus kinases (JAKs) are required for T-effector cell responses in different inflammatory diseases, and their blockade could potently reduce acute GVHD. We observed that inhibition of JAK1/2 signaling resulted in reduced proliferation of effector T cells and suppression of proinflammatory cytok...    »
 
Zeitschriftentitel:
Blood 
Jahr:
2014 
Band / Volume:
123 
Heft / Issue:
24 
Seitenangaben Beitrag:
3832-42 
Sprache:
eng 
Print-ISSN:
0006-4971 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik