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Dokumenttyp:
journal article 
Autor(en):
Graf, Nicolas; Li, Zhoulei; Herrmann, Ken; Weh, Daniel; Aichler, Michaela; Slawska, Jolanta; Walch, Axel; Peschel, Christian; Schwaiger, Markus; Buck, Andreas K; Dechow, Tobias; Keller, Ulrich 
Titel:
Positron emission tomographic monitoring of dual phosphatidylinositol-3-kinase and mTOR inhibition in anaplastic large cell lymphoma. 
Abstract:
Dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibition offers an attractive therapeutic strategy in anaplastic large cell lymphoma depending on oncogenic nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) signaling. We tested the efficacy of a novel dual PI3K/mTOR inhibitor, NVP-BGT226 (BGT226), in two anaplastic large cell lymphoma cell lines in vitro and in vivo and performed an early response evaluation with positron emission tomography (PET) imaging using t...    »
 
Zeitschriftentitel:
Onco Targets Ther 
Jahr:
2014 
Band / Volume:
Seitenangaben Beitrag:
789-98 
Sprache:
eng 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik; Nuklearmedizinische Klinik und Poliklinik