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Dokumenttyp:
journal article 
Autor(en):
Hoellein, Alexander; Fallahi, Mohammad; Schoeffmann, Stephanie; Steidle, Sabine; Schaub, Franz X; Rudelius, Martina; Laitinen, Iina; Nilsson, Lisa; Goga, Andrei; Peschel, Christian; Nilsson, Jonas A; Cleveland, John L; Keller, Ulrich 
Titel:
Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma. 
Abstract:
Myc oncogenic transcription factors (c-Myc, N-Myc, and L-Myc) coordinate the control of cell growth, division, and metabolism. In cancer, Myc overexpression is often associated with aggressive disease, which is in part due to the destruction of select targets by the ubiquitin-proteasome system (eg, SCF(Skp2)-directed destruction of the Cdk inhibitor p27(Kip1)). We reasoned that Myc would also regulate SUMOylation, a related means of posttranslational modification of proteins, and that this circu...    »
 
Zeitschriftentitel:
Blood 
Jahr:
2014 
Band / Volume:
124 
Heft / Issue:
13 
Seitenangaben Beitrag:
2081-90 
Sprache:
eng 
Print-ISSN:
0006-4971 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik; Nuklearmedizinische Klinik und Poliklinik