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Document type:
journal article 
Author(s):
Hoellein, Alexander; Fallahi, Mohammad; Schoeffmann, Stephanie; Steidle, Sabine; Schaub, Franz X; Rudelius, Martina; Laitinen, Iina; Nilsson, Lisa; Goga, Andrei; Peschel, Christian; Nilsson, Jonas A; Cleveland, John L; Keller, Ulrich 
Title:
Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma. 
Abstract:
Myc oncogenic transcription factors (c-Myc, N-Myc, and L-Myc) coordinate the control of cell growth, division, and metabolism. In cancer, Myc overexpression is often associated with aggressive disease, which is in part due to the destruction of select targets by the ubiquitin-proteasome system (eg, SCF(Skp2)-directed destruction of the Cdk inhibitor p27(Kip1)). We reasoned that Myc would also regulate SUMOylation, a related means of posttranslational modification of proteins, and that this circu...    »
 
Journal title abbreviation:
Blood 
Year:
2014 
Journal volume:
124 
Journal issue:
13 
Pages contribution:
2081-90 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
III. Medizinische Klinik und Poliklinik; Nuklearmedizinische Klinik und Poliklinik