Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Baumann, Ursula; Fernández-Sáiz, Vanesa; Rudelius, Martina; Lemeer, Simone; Rad, Roland; Knorn, Anna-Maria; Slawska, Jolanta; Engel, Katharina; Jeremias, Irmela; Li, Zhoulei; Tomiatti, Viktoriya; Illert, Anna-Lena; Targosz, Bianca-Sabrina; Braun, Martin; Perner, Sven; Leitges, Michael; Klapper, Wolfram; Dreyling, Martin; Miething, Cornelius; Lenz, Georg; Rosenwald, Andreas; Peschel, Christian; Keller, Ulrich; Kuster, Bernhard; Bassermann, Florian 
Titel:
Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis. 
Abstract:
We searched for genetic alterations in human B cell lymphoma that affect the ubiquitin-proteasome system. This approach identified FBXO25 within a minimal common region of frequent deletion in mantle cell lymphoma (MCL). FBXO25 encodes an orphan F-box protein that determines the substrate specificity of the SCF (SKP1-CUL1-F-box)(FBXO25) ubiquitin ligase complex. An unbiased screen uncovered the prosurvival protein HCLS1-associated protein X-1 (HAX-1) as the bona fide substrate of FBXO25 that is...    »
 
Zeitschriftentitel:
Nat Med 
Jahr:
2014 
Band / Volume:
20 
Heft / Issue:
12 
Seitenangaben Beitrag:
1401-9 
Sprache:
eng 
Print-ISSN:
1078-8956 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik