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Dokumenttyp:
journal article 
Autor(en):
Arnold-Schrauf, Catharina; Dudek, Markus; Dielmann, Anastasia; Pace, Luigia; Swallow, Maxine; Kruse, Friederike; Kühl, Anja A; Holzmann, Bernhard; Berod, Luciana; Sparwasser, Tim 
Titel:
Dendritic cells coordinate innate immunity via MyD88 signaling to control Listeria monocytogenes infection. 
Abstract:
Listeria monocytogenes (LM), a facultative intracellular Gram-positive pathogen, can cause life-threatening infections in humans. In mice, the signaling cascade downstream of the myeloid differentiation factor 88 (MyD88) is essential for proper innate immune activation against LM, as MyD88-deficient mice succumb early to infection. Here, we show that MyD88 signaling in dendritic cells (DCs) is sufficient to mediate the protective innate response, including the production of proinflammatory cytok...    »
 
Zeitschriftentitel:
Cell Rep 
Jahr:
2014 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
698-708 
Sprache:
eng 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik