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Document type:
Journal Article; Review 
Author(s):
Löhr, J Matthias; Haas, Stephan L; Kröger, Jens C; Friess, Helmut M; Höft, Raimund; Goretzki, Peter E; Peschel, Christian; Schweigert, Markus; Salmons, Brian; Gunzburg, Walter H 
Title:
Encapsulated cells expressing a chemotherapeutic activating enzyme allow the targeting of subtoxic chemotherapy and are safe and efficacious: data from two clinical trials in pancreatic cancer. 
Abstract:
Despite progress in the treatment of pancreatic cancer, there is still a need for improved therapies. In this manuscript, we report clinical experience with a new therapy for the treatment of pancreatic cancer involving the implantation of encapsulated cells over-expressing a cytochrome P450 enzyme followed by subsequent low-dose ifosfamide administrations as a means to target activated ifosfamide to the tumor. The safety and efficacy of the angiographic instillation of encapsulated allogeneic c...    »
 
Journal title abbreviation:
Pharmaceutics 
Year:
2014 
Journal volume:
Journal issue:
Pages contribution:
447-66 
Language:
eng 
TUM Institution:
Chirurgische Klinik und Poliklinik; III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)