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Document type:
journal article 
Author(s):
Lunardi, Serena; Jamieson, Nigel B; Lim, Su Yin; Griffiths, Kristin L; Carvalho-Gaspar, Manuela; Al-Assar, Osama; Yameen, Sabira; Carter, Ross C; McKay, Colin J; Spoletini, Gabriele; D'Ugo, Stefano; Silva, Michael A; Sansom, Owen J; Janssen, Klaus-Peter; Muschel, Ruth J; Brunner, Thomas B 
Title:
IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival. 
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant desmoplastic reaction driven by pancreatic stellate cells (PSCs) that contributes to tumor progression. Here we sought to characterize the interactions between pancreatic cancer cells (PCCs) and PSCs that affect the inflammatory and immune response in pancreatic tumors. Conditioned media from mono- and cocultures of PSCs and PCCs were assayed for expression of cytokines and growth factors. IP-10/CXCL10 was the most highly in...    »
 
Journal title abbreviation:
Oncotarget 
Year:
2014 
Journal volume:
Journal issue:
22 
Pages contribution:
11064-80 
Language:
eng 
TUM Institution:
Chirurgiesche Klinik und Poliklinik