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Document type:
journal article 
Author(s):
Multhoff, Gabriele; Radons, Jürgen; Vaupel, Peter 
Title:
Critical role of aberrant angiogenesis in the development of tumor hypoxia and associated radioresistance. 
Abstract:
Newly formed microvessels in most solid tumors show an abnormal morphology and thus do not fulfil the metabolic demands of the growing tumor mass. Due to the chaotic and heterogeneous tumor microcirculation, a hostile tumor microenvironment develops, that is characterized inter alia by local hypoxia, which in turn can stimulate the HIF-system. The latter can lead to tumor progression and may be involved in hypoxia-mediated radioresistance of tumor cells. Herein, cellular and molecular mechanisms...    »
 
Journal title abbreviation:
Cancers (Basel) 
Year:
2014 
Journal volume:
Journal issue:
Pages contribution:
813-28 
Language:
eng 
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie