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Document type:
journal article 
Author(s):
Harrison, David K; Vaupel, Peter 
Title:
Heterogeneity in tissue oxygenation: from physiological variability in normal tissues to pathophysiological chaos in malignant tumours. 
Abstract:
Heterogeneity is a feature of both normal oxygen supply to tissue and of a supply that is disturbed due to a wide range of different pathologies. Here, the physiological importance of heterogeneity of tissue oxygenation is revisited. The anatomical and functional basis for heterogeneity of blood flow, local and regional regulatory mechanisms in normal tissues and the pathophysiology of the failure of regulation will be examined.Under physiological conditions, regulation of blood flow distributio...    »
 
Journal title abbreviation:
Adv Exp Med Biol 
Year:
2014 
Journal volume:
812 
Pages contribution:
25-31 
Language:
eng 
Print-ISSN:
0065-2598 
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie