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Document type:
journal article 
Author(s):
Mayer, Arnulf; Schmidt, Marcus; Seeger, Alexander; Serras, André Franke; Vaupel, Peter; Schmidberger, Heinz 
Title:
GLUT-1 expression is largely unrelated to both hypoxia and the Warburg phenotype in squamous cell carcinomas of the vulva. 
Abstract:
Strongly increased uptake of glucose is a hallmark of solid malignant tumors. This phenotype can be triggered by hypoxia-induced gene expression changes or can occur independently of hypoxia as a consequence of malignant transformation itself, and is often referred to as the Warburg effect. The glycolytic phenotype has been associated with malignant progression and resistance to radio- and chemotherapy.We have chosen squamous cell carcinomas of the vulva (SCC-V) as a representative solid tumor e...    »
 
Journal title abbreviation:
BMC Cancer 
Year:
2014 
Journal volume:
14 
Pages contribution:
760 
Language:
eng 
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie