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Document type:
journal article 
Author(s):
Vaupel, Peter; Mayer, Arnulf 
Title:
Hypoxia in tumors: pathogenesis-related classification, characterization of hypoxia subtypes, and associated biological and clinical implications. 
Abstract:
Hypoxia is a hallmark of tumors leading to (mal-)adaptive processes, development of aggressive phenotypes and treatment resistance. Based on underlying mechanisms and their duration, two main types of hypoxia have been identified, coexisting with complex spatial and temporal heterogeneities. Chronic hypoxia is mainly caused by diffusion limitations due to enlarged diffusion distances and adverse diffusion geometries (e.g., concurrent vs. countercurrent microvessels, Krogh- vs. Hill-type diffusio...    »
 
Journal title abbreviation:
Adv Exp Med Biol 
Year:
2014 
Journal volume:
812 
Pages contribution:
19-24 
Language:
eng 
Print-ISSN:
0065-2598 
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie