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Dokumenttyp:
journal article 
Autor(en):
Roeder, Falk; Ulrich, Alexis; Habl, Gregor; Uhl, Matthias; Saleh-Ebrahimi, Ladan; Huber, Peter E; Schulz-Ertner, Daniela; Nikoghosyan, Anna V; Alldinger, Ingo; Krempien, Robert; Mechtersheimer, Gunhild; Hensley, Frank W; Debus, Juergen; Bischof, Marc 
Titel:
Clinical phase I/II trial to investigate preoperative dose-escalated intensity-modulated radiation therapy (IMRT) and intraoperative radiation therapy (IORT) in patients with retroperitoneal soft tissue sarcoma: interim analysis. 
Abstract:
To report an unplanned interim analysis of a prospective, one-armed, single center phase I/II trial (NCT01566123).Between 2007 and 2013, 27 patients (pts) with primary/recurrent retroperitoneal sarcomas (size> 5 cm, M0, at least marginally resectable) were enrolled. The protocol attempted neoadjuvant IMRT using an integrated boost with doses of 45-50 Gy to PTV and 50-56 Gy to GTV in 25 fractions, followed by surgery and IOERT (10-12 Gy). Primary endpoint was 5-year-LC, secondary endpoints includ...    »
 
Zeitschriftentitel:
BMC Cancer 
Jahr:
2014 
Band / Volume:
14 
Seitenangaben Beitrag:
617 
Sprache:
eng 
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie