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Document type:
journal article 
Author(s):
Rauch, Anke; Hennig, Dorle; Schäfer, Claudia; Wirth, Matthias; Marx, Christian; Heinzel, Thorsten; Schneider, Günter; Krämer, Oliver H 
Title:
Survivin and YM155: how faithful is the liaison? 
Abstract:
Survivin belongs to the family of apoptosis inhibitors (IAPs), which antagonizes the induction of cell death. Dysregulated expression of IAPs is frequently observed in cancers, and the high levels of survivin in tumors compared to normal adult tissues make it an attractive target for pharmacological interventions. The small imidazolium-based compound YM155 has recently been reported to block the expression of survivin via inhibition of the survivin promoter. Recent data, however, question that t...    »
 
Journal title abbreviation:
BBA - Rev Cancer 
Year:
2014 
Journal volume:
1845 
Journal issue:
Pages contribution:
202-20 
Language:
eng 
Print-ISSN:
0304-419X 
TUM Institution:
II. Medizinische Klinik und Poliklinik