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Dokumenttyp:
journal article 
Autor(en):
Sathe, A; Guerth, F; Cronauer, M V; Heck, M M; Thalgott, M; Gschwend, J E; Retz, M; Nawroth, R 
Titel:
Mutant PIK3CA controls DUSP1-dependent ERK 1/2 activity to confer response to AKT target therapy. 
Abstract:
Alterations in the phosphoinositide 3-kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) signalling pathway are frequent in urothelial bladder cancer (BLCA) and thus provide a potential target for novel therapeutic strategies. We investigated the efficacy of the AKT inhibitor MK-2206 in BLCA and the molecular determinants that predict therapy response.Biochemical and functional effects of the AKT inhibitor MK-2206 were analysed on a panel of 11 BLCA cell lines possessing different genetic...    »
 
Zeitschriftentitel:
Br J Cancer 
Jahr:
2014 
Band / Volume:
111 
Heft / Issue:
11 
Seitenangaben Beitrag:
2103-13 
Sprache:
eng 
Print-ISSN:
0007-0920 
TUM Einrichtung:
Urologische Klinik und Poliklinik