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Dokumenttyp:
journal article 
Autor(en):
Guo, Shihui; Skala, Wolfgang; Magdolen, Viktor; Brandstetter, Hans; Goettig, Peter 
Titel:
Sweetened kallikrein-related peptidases (KLKs): glycan trees as potential regulators of activation and activity. 
Abstract:
Most kallikrein-related peptidases (KLKs) are N-glycosylated with N-acetylglucosamine2-mannose9 units at Asn-Xaa-Ser/Thr sequons during protein synthesis and translocation into the endoplasmic reticulum. These N-glycans are modified in the Golgi machinery, where additional O-glycosylation at Ser and Thr takes place, before exocytotic release of the KLKs into the extracellular space. Sequons are present in all 15 members of the KLKs and comparative studies for KLKs from natural and recombinant so...    »
 
Zeitschriftentitel:
Biol Chem 
Jahr:
2014 
Band / Volume:
395 
Heft / Issue:
Seitenangaben Beitrag:
959-76 
Sprache:
eng 
Print-ISSN:
1431-6730 
TUM Einrichtung:
Frauenklinik und Poliklinik