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Document type:
journal article 
Author(s):
Gewies, Andreas; Gorka, Oliver; Bergmann, Hanna; Pechloff, Konstanze; Petermann, Franziska; Jeltsch, Katharina M; Rudelius, Martina; Kriegsmann, Mark; Weichert, Wilko; Horsch, Marion; Beckers, Johannes; Wurst, Wolfgang; Heikenwalder, Mathias; Korn, Thomas; Heissmeyer, Vigo; Ruland, Jürgen 
Title:
Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation. 
Abstract:
The paracaspase Malt1 is a central regulator of antigen receptor signaling that is frequently mutated in human lymphoma. As a scaffold, it assembles protein complexes for NF-?B activation, and its proteolytic domain cleaves negative NF-?B regulators for signal enforcement. Still, the physiological functions of Malt1-protease are unknown. We demonstrate that targeted Malt1-paracaspase inactivation induces a lethal inflammatory syndrome with lymphocyte-dependent neurodegeneration in vivo. Paracasp...    »
 
Journal title abbreviation:
Cell Rep 
Year:
2014 
Journal volume:
Journal issue:
Pages contribution:
1292-305 
Language:
eng 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; Institut für Virologie; Neurologische Klinik und Poliklinik