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Dokumenttyp:
journal article 
Autor(en):
Nothdurfter, C; Tanasic, S; Di Benedetto, B; Uhr, M; Wagner, EM; Gilling, KE; Parsons, CG; Rein, T; Holsboer, F; Rupprecht, R; Rammes, G 
Titel:
Lipid raft integrity affects GABAA receptor, but not NMDA receptor modulation by psychopharmacological compounds. 
Abstract:
Lipid rafts have been shown to play an important role for G-protein mediated signal transduction and the function of ligand-gated ion channels including their modulation by psychopharmacological compounds. In this study, we investigated the functional significance of the membrane distribution of NMDA and GABAA receptor subunits in relation to the accumulation of the tricyclic antidepressant desipramine (DMI) and the benzodiazepine diazepam (Diaz). In the presence of Triton X-100, which allowed p...    »
 
Zeitschriftentitel:
Int J Neuropsychopharmacol 
Jahr:
2013 
Band / Volume:
16 
Heft / Issue:
Seitenangaben Beitrag:
1361-71 
Sprache:
eng 
Print-ISSN:
1461-1457 
TUM Einrichtung:
Klinik für Anästhesiologie