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Dokumenttyp:
journal article 
Autor(en):
Gautheron, Jérémie; Vucur, Mihael; Reisinger, Florian; Cardenas, David Vargas; Roderburg, Christoph; Koppe, Christiane; Kreggenwinkel, Karina; Schneider, Anne Theres; Bartneck, Matthias; Neumann, Ulf Peter; Canbay, Ali; Reeves, Helen Louise; Luedde, Mark; Tacke, Frank; Trautwein, Christian; Heikenwalder, Mathias; Luedde, Tom 
Titel:
A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis. 
Abstract:
Non-alcoholic fatty liver disease (NAFLD) represents the most common liver disease in Western countries and often progresses to non-alcoholic steatohepatitis (NASH) leading ultimately to liver fibrosis and liver cancer. The occurrence of hepatocyte cell death-so far characterized as hepatocyte apoptosis-represents a fundamental step from benign steatosis toward progressive steatohepatitis. In contrast, the function of RIP3-dependent "necroptosis" in NASH and NASH-induced fibrosis is currently un...    »
 
Zeitschriftentitel:
EMBO Mol Med 
Jahr:
2014 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
1062-74 
Sprache:
eng 
Print-ISSN:
1757-4676 
TUM Einrichtung:
Institut für Virologie