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Document type:
journal article 
Author(s):
Boettcher, Steffen, S; Gerosa, Rahel, R; Radpour, Ramin, R; Bauer, Judith, J; Ampenberger, Franziska, F; Heikenwalder, Mathias, M; Kopf, Manfred, M; Manz, Markus G, MG 
Title:
Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis. 
Abstract:
Systemic bacterial infection induces a hematopoietic response program termed "emergency granulopoiesis" that is characterized by increased de novo bone marrow (BM) neutrophil production. How loss of local immune control and bacterial dissemination is sensed and subsequently translated into the switch from steady-state to emergency granulopoiesis is, however, unknown. Using tissue-specific myeloid differentiation primary response gene 88 (Myd88)-deficient mice and in vivo lipopolysaccharide (LPS)...    »
 
Journal title abbreviation:
Blood 
Year:
2014 
Journal volume:
124 
Journal issue:
Pages contribution:
1393-403 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
Institut für Virologie