User: Guest  Login
Document type:
journal article 
Author(s):
Bassermann, F; Eichner, R; Pagano, M 
Title:
The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer. 
Abstract:
Two families of E3 ubiquitin ligases are prominent in cell cycle regulation and mediate the timely and precise ubiquitin-proteasome-dependent degradation of key cell cycle proteins: the SCF (Skp1/Cul1/F-box protein) complex and the APC/C (anaphase promoting complex or cyclosome). While certain SCF ligases drive cell cycle progression throughout the cell cycle, APC/C (in complex with either of two substrate recruiting proteins: Cdc20 and Cdh1) orchestrates exit from mitosis (APC/C(Cdc20)) and est...    »
 
Journal title abbreviation:
BBA - MOL CELL RES 
Year:
2014 
Journal volume:
1843 
Journal issue:
Pages contribution:
150-62 
Language:
eng 
Print-ISSN:
0167-4889 
TUM Institution:
III. Medizinische Klinik und Poliklinik