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Dokumenttyp:
journal article 
Autor(en):
Sundqvist, Emilie; Buck, Dorothea; Warnke, Clemens; Albrecht, Eva; Gieger, Christian; Khademi, Mohsen; Lima Bomfim, Izaura; Fogdell-Hahn, Anna; Link, Jenny; Alfredsson, Lars; Søndergaard, Helle Bach; Hillert, Jan; International Multiple Sclerosis Genetics Consortium; Oturai, Annette B; Hemme, Bernhard; Kockum, Ingrid; Olsson, Tomas; Barcellos, Lisa; Booth, David; McCauley, Jacob L; Comabella, Manuel; Compston, Alastair; DAlfonso, Sandra; De Jager, Philip; Fontaine, Bertrand; Goris, An; Hafler, D...    »
 
Titel:
JC polyomavirus infection is strongly controlled by human leucocyte antigen class II variants. 
Abstract:
JC polyomavirus (JCV) carriers with a compromised immune system, such as in HIV, or subjects on immune-modulating therapies, such as anti VLA-4 therapy may develop progressive multifocal leukoencephalopathy (PML) which is a lytic infection of oligodendrocytes in the brain. Serum antibodies to JCV mark infection occur only in 50-60% of infected individuals, and high JCV-antibody titers seem to increase the risk of developing PML. We here investigated the role of human leukocyte antigen (HLA), ins...    »
 
Zeitschriftentitel:
PLoS Pathog 
Jahr:
2014 
Band / Volume:
10 
Heft / Issue:
Seitenangaben Beitrag:
e1004084 
Sprache:
eng 
Print-ISSN:
1553-7366 
TUM Einrichtung:
Neurologische Klinik und Poliklinik