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Dokumenttyp:
journal article 
Autor(en):
Rokavec, Matjaz; Öner, Meryem Gülfem; Li, Huihui; Jackstadt, Rene; Jiang, Longchang; Lodygin, Dmitri; Kaller, Markus; Horst, David; Ziegler, Paul K; Schwitalla, Sarah; Slotta-Huspenina, Julia; Bader, Franz G; Greten, Florian R; Hermeking, Heiko 
Titel:
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. 
Abstract:
Members of the miR-34 family are induced by the tumor suppressor p53 and are known to inhibit epithelial-to-mesenchymal transition (EMT) and therefore presumably suppress the early phases of metastasis. Here, we determined that exposure of human colorectal cancer (CRC) cells to the cytokine IL-6 activates the oncogenic STAT3 transcription factor, which directly represses the MIR34A gene via a conserved STAT3-binding site in the first intron. Repression of MIR34A was required for IL-6-induced EMT...    »
 
Zeitschriftentitel:
J Clin Invest 
Jahr:
2014 
Band / Volume:
124 
Heft / Issue:
Seitenangaben Beitrag:
1853-67 
Sprache:
eng 
Print-ISSN:
0021-9738 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie