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Dokumenttyp:
Zeitschriftenaufsatz 
Autor(en):
Zitzmann, Kathrin; De Toni, Enrico N.; Brand, Stephan; Göke, Burkhard; Meinecke, Jennifer; Spöttl, Gerald; Meyer, Heinrich H.D.; Auernhammer, Christoph J. 
Titel:
The Novel mTOR Inhibitor RAD001 (Everolimus) Induces Antiproliferative Effects in Human Pancreatic Neuroendocrine Tumor Cells 
Abstract:
Background/Aim: Tumors exhibiting constitutively activated PI(3)K/Akt/mTOR signaling are hypersensitive to mTOR inhibitors such as RAD001 (everolimus) which is presently being investigated in clinical phase II trials in various tumor entities, including neuroendocrine tumors (NETs). However, no preclinical data about the effects of RAD001 on NET cells have been published. In this study, we aimed to evaluate the effects of RAD001 on BON cells, a human pancreatic NET cell line that exhibits consti...    »
 
Stichworte:
Neuroendocrine tumor; mTOR; RAD001; Cell proliferation; Cell cycle; Apoptosis 
Zeitschriftentitel:
Neuroendocrinology 
Jahr:
2007 
Band / Volume:
85 
Heft / Issue:
Seitenangaben Beitrag:
54--60 
Verlag / Institution:
S. Karger AG 
Verlagsort:
Basel, Switzerland 
Print-ISSN:
1423-0194 
E-ISSN:
1423-0194 
Hinweise:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.