User: Guest  Login
Author(s):
Spiwoks-Becker, Isabella; Wolloscheck, Tanja; Rickes, Oliver; Kelleher, Debra K.; Rohleder, Nils; Weyer, Veronika; Spessert, Rainer 
Title:
Phosphodiesterase 10A in the Rat Pineal Gland: Localization, Daily and Seasonal Regulation of Expression and Influence on Signal Transduction 
Abstract:
The cyclic nucleotide phosphodiesterase 10A (PDE10A) is highly expressed in striatal spiny projection neurons and represents a therapeutic target for the treatment of psychotic symptoms. As reported previously [J Biol Chem 2009; 284:7606–7622], in this study PDE10A was seen to be additionally expressed in the pineal gland where the levels of PDE10A transcript display daily changes. As with the transcript, the amount of PDE10A protein was found to be under daily and seasonal regulation. The obse...    »
 
Keywords:
Phosphodiesterase 10A; Circadian system; Pineal gland; Norepinephrine; cAMP; cGMP; Arylalkylamine N-acetyltransferase 
Journal title:
Neuroendocrinology 
Year:
2011 
Journal volume:
94 
Journal issue:
Pages contribution:
113--123 
Publisher:
S. Karger AG 
Publisher address:
Basel, Switzerland 
Print-ISSN:
1423-0194 
E-ISSN:
1423-0194 
Notes:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.