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Author(s):
Umgelter, Andreas; Reindl, Wolfgang; Lutz, Jens; Kreymann, Bernhard; Ronco, Claudio; Huber, Wolfgang; Frank, Helga; Schmid, Roland M.; Heemann, Uwe 
Title:
Treatment of Septic Patients with an Arginine-Based Endotoxin Adsorber Column Improves Hemodynamics and Reduces Oxidative Stress: Results of a Feasibility Study 
Abstract:
Background: Mortality of severe sepsis and septic shock is unacceptably high. Adsorptive removal of endotoxin may interrupt the inflammatory cascade triggered by lipopolysaccharide. Methods: Prospective feasibility study with plasma separation and adsorption (PSA) treatment using a novel arginine-coated adsorber column was performed in a tertiary care gastroenterological intensive care unit. Results: 10 patients with severe sepsis/septic shock (median APACHE II score: 27, hospital mortality 40%)...    »
 
Keywords:
Sepsis; Shock; septic; Endotoxemia; Plasmapheresis; Adsorption; Advanced oxidation protein products 
Journal title:
Blood Purification 
Year:
2008 
Journal volume:
26 
Journal issue:
Pages contribution:
333--339 
Fulltext / DOI:
Publisher:
S. Karger AG 
Publisher address:
Basel, Switzerland 
Print-ISSN:
1421-9735 
E-ISSN:
1421-9735 
Notes:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.