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Dokumenttyp:
journal article 
Autor(en):
Serve, Hubert; Krug, Utz; Wagner, Ruth; Sauerland, M Cristina; Heinecke, Achim; Brunnberg, Uta; Schaich, Markus; Ottmann, Oliver; Duyster, Justus; Wandt, Hannes; Fischer, Thomas; Giagounidis, Aristoteles; Neubauer, Andreas; Reichle, Albrecht; Aulitzky, Walter; Noppeney, Richard; Blau, Igor; Kunzmann, Volker; Stuhlmann, Reingard; Krämer, Alwin; Kreuzer, Karl-Anton; Brandts, Christian; Steffen, Björn; Thiede, Christian; Müller-Tidow, Carsten; Ehninger, Gerhard; Berdel, Wolfgang E 
Titel:
Sorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: results from a randomized, placebo-controlled trial. 
Abstract:
The prognosis of elderly patients with acute myeloid leukemia (AML) is still dismal even with intensive chemotherapy. In this trial, we compared the antileukemic activity of standard induction and consolidation therapy with or without the addition of the kinase inhibitor sorafenib in elderly patients with AML.All patients received standard cytarabine and daunorubicin induction (7+3 regimen) and up to two cycles of intermediate-dose cytarabine consolidation. Two hundred one patients were equally...    »
 
Zeitschriftentitel:
J Clin Oncol 
Jahr:
2013 
Band / Volume:
31 
Heft / Issue:
25 
Seitenangaben Beitrag:
3110-8 
Sprache:
eng 
Print-ISSN:
0732-183X 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik