User: Guest  Login
Document type:
journal article 
Author(s):
Felmy, B; Songhet, P; Slack, EM; Müller, AJ; Kremer, M; Van Maele, L; Cayet, D; Heikenwalder, M; Sirard, JC; Hardt, WD 
Title:
NADPH Oxidase Deficient Mice Develop Colitis and Bacteremia upon Infection with Normally Avirulent, TTSS-1- and TTSS-2-Deficient Salmonella Typhimurium. 
Abstract:
Infections, microbe sampling and occasional leakage of commensal microbiota and their products across the intestinal epithelial cell layer represent a permanent challenge to the intestinal immune system. The production of reactive oxygen species by NADPH oxidase is thought to be a key element of defense. Patients suffering from chronic granulomatous disease are deficient in one of the subunits of NADPH oxidase. They display a high incidence of Crohn's disease-like intestinal inflammation and are...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2013 
Journal volume:
Journal issue:
10 
Pages contribution:
e77204 
Language:
eng 
TUM Institution:
Institut für Virologie