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Dokumenttyp:
journal article 
Autor(en):
Vucur, M; Reisinger, F; Gautheron, J; Janssen, J; Roderburg, C; Cardenas, DV; Kreggenwinkel, K; Koppe, C; Hammerich, L; Hakem, R; Unger, K; Weber, A; Gassler, N; Luedde, M; Frey, N; Neumann, UP; Tacke, F; Trautwein, C; Heikenwalder, M; Luedde, T 
Titel:
RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation. 
Abstract:
For years, the term "apoptosis" was used synonymously with programmed cell death. However, it was recently discovered that receptor interacting protein 3 (RIP3)-dependent "necroptosis" represents an alternative programmed cell death pathway activated in many inflamed tissues. Here, we show in a genetic model of chronic hepatic inflammation that activation of RIP3 limits immune responses and compensatory proliferation of liver parenchymal cells (LPC) by inhibiting Caspase-8-dependent activation o...    »
 
Zeitschriftentitel:
Cell Rep 
Jahr:
2013 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
776-90 
Sprache:
eng 
TUM Einrichtung:
Institut für Virologie