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Dokumenttyp:
journal article 
Autor(en):
Wirth, Manfred; Heidenreich, Axel; Gschwend, Jürgen E; Gil, Thierry; Zastrow, Stefan; Laniado, Michael; Gerloff, Joachim; Zühlsdorf, Michael; Mordenti, Giacomo; Uhl, Wolfgang; Lannert, Heinrich 
Titel:
A Multicenter Phase 1 Study of EMD 525797 (DI17E6), a Novel Humanized Monoclonal Antibody Targeting ?v Integrins, in Progressive Castration-resistant Prostate Cancer with Bone Metastases After Chemotherapy. 
Abstract:
EMD 525797 (DI17E6) is a deimmunized, humanized monoclonal immunoglobulin G2 antibody against the ?v subunit of human integrins. Blocking ?v integrins may be an effective strategy for inhibiting prostate cancer (PCa) metastasis.Evaluate EMD 525797 safety/tolerability and pharmacokinetics (PK) in castration-resistant PCa patients. Secondary objectives included antitumor activity assessments.A phase 1 open-label study in 26 patients (four European centers). Eligible patients (>=18 yr) had histolog...    »
 
Zeitschriftentitel:
Eur Urol 
Jahr:
2014 
Band / Volume:
65 
Heft / Issue:
Seitenangaben Beitrag:
897-904 
Sprache:
eng 
Print-ISSN:
0302-2838 
TUM Einrichtung:
Urologische Klinik und Poliklinik