Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Loga, Florian; Domes, Katrin; Freichel, Marc; Flockerzi, Veit; Dietrich, Alexander; Birnbaumer, Lutz; Hofmann, Franz; Wegener, Jörg W 
Titel:
The role of cGMP/cGKI signalling and Trpc channels in regulation of vascular tone. 
Abstract:
Signalling via cGMP-dependent protein kinase I (cGKI) is the major pathway in vascular smooth muscle (SM), by which endothelial NO regulates vascular tone. Recent evidence suggests that canonical transient receptor potential (Trpc) channels are targets of cGKI in SM and mediate the relaxant effects of cGMP signalling. We tested this concept by investigating the role of cGMP/cGKI signalling on vascular tone and peripheral resistance using Trpc6(-/-), Trpc3(-/-), Trpc3(-/-)/6(-/-), Trpc1(-/-)/3(-/...    »
 
Zeitschriftentitel:
Cardiovasc Res 
Jahr:
2013 
Band / Volume:
100 
Heft / Issue:
Seitenangaben Beitrag:
280-7 
Sprache:
eng 
Print-ISSN:
0008-6363 
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie