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Document type:
journal article 
Author(s):
Ganesan, Jayavarshni; Ramanujam, Deepak; Sassi, Yassine; Ahles, Andrea; Jentzsch, Claudia; Werfel, Stanislas; Leierseder, Simon; Loyer, Xavier; Giacca, Mauro; Zentilin, Lorena; Thum, Thomas; Laggerbauer, Bernhard; Engelhardt, Stefan 
Title:
MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors. 
Abstract:
Several microRNAs (miRs) have been shown to regulate gene expression in the heart, and dysregulation of their expression has been linked to cardiac disease. miR-378 is strongly expressed in the mammalian heart but so far has been studied predominantly in cancer, in which it regulates cell survival and tumor growth.Here, we report tight control of cardiomyocyte hypertrophy through miR-378. In isolated primary cardiomyocytes, miR-378 was found to be both necessary and sufficient to repress cardiom...    »
 
Journal title abbreviation:
Circulation 
Year:
2013 
Journal volume:
127 
Journal issue:
21 
Pages contribution:
2097-106 
Language:
eng 
Print-ISSN:
0009-7322 
TUM Institution:
Institut für Pharmakologie und Toxikologie