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Dokumenttyp:
journal article 
Autor(en):
Blank, Susanne; Rachakonda, Sivaramakrishna; Keller, Gisela; Weichert, Wilko; Lordick, Florian; Langer, Rupert; Springfeld, Christoph; Bruckner, Thomas; Becker, Karen; Kumar, Rajiv; Ott, Katja 
Titel:
A retrospective comparative exploratory study on two Methylentetrahydrofolate Reductase (MTHFR) polymorphisms in esophagogastric cancer: the A1298C MTHFR polymorphism is an independent prognostic factor only in neoadjuvantly treated gastric cancer patient 
Abstract:
Methylentetrahydrofolate reductase (MTHFR) plays a major role in folate metabolism and consequently could be an important factor for the efficacy of a treatment with 5-fluorouracil. Our aim was to evaluate the prognostic and predictive value of two well characterized constitutional MTHFR gene polymorphisms for primarily resected and neoadjuvantly treated esophagogastric adenocarcinomas.569 patients from two centers were analyzed (gastric cancer: 218, carcinoma of the esophagogastric junction (AE...    »
 
Zeitschriftentitel:
BMC Cancer 
Jahr:
2014 
Band / Volume:
14 
Seitenangaben Beitrag:
58 
Sprache:
eng 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie