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Dokumenttyp:
journal article 
Autor(en):
Pickhard, A; Piontek, G; Seidl, C; Kopping, S; Blechert, B; Mißlbeck, M; Brockhoff, G; Bruchertseifer, F; Morgenstern, A; Essler, M 
Titel:
(213)Bi-anti-EGFR radioimmunoconjugates and X-ray irradiation trigger different cell death pathways in squamous cell carcinoma cells. 
Abstract:
Treatment of patients with squamous cell carcinoma of head and neck is hampered by resistance of tumor cells to irradiation. Additional therapies enhancing the effect of X-ray irradiation may be beneficial. Antibodies targeting EGFR have been shown to improve the efficacy of radiation therapy. Therefore, we analyzed cytotoxicity of (213)Bi-anti-EGFR immunoconjugates in combination with X-ray irradiation.The monoclonal anti-EGFR antibody matuzumab was coupled to CHX-A"-DTPA forming stable complex...    »
 
Zeitschriftentitel:
Nucl Med Biol 
Jahr:
2014 
Band / Volume:
41 
Heft / Issue:
Seitenangaben Beitrag:
68-76 
Sprache:
eng 
Print-ISSN:
0969-8051 
TUM Einrichtung:
Hals-, Nasen-, Ohrenklinik und Poliklinik; Nuklearmedizinische Klinik und Poliklinik