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Dokumenttyp:
journal article 
Autor(en):
Kieseier, Bernd C; Stüve, Olaf; Dehmel, Thomas; Goebels, Norbert; Leussink, Verena I; Mausberg, Anne K; Ringelstein, Marius; Turowski, Bernd; Aktas, Orhan; Antoch, Gerald; Hartung, Hans-Peter 
Titel:
Disease amelioration with tocilizumab in a treatment-resistant patient with neuromyelitis optica: implication for cellular immune responses. 
Abstract:
Neuromyelitis optica (NMO) is an autoimmune disease of the central nervous system in which aberrant antibody responses to the astrocytic water channel aquaporin 4 have been described. Experimental evidence is emerging that NMO is partly driven by the proinflammatory cytokine interleukin 6 (IL-6), which propagates the survival of disease-specific B cell subclasses, and deviates CD4+ T helper cell differentiation toward IL-17-producing T helper 17 cells. Tocilizumab is a recombinant humanized mono...    »
 
Zeitschriftentitel:
JAMA Neurol 
Jahr:
2013 
Band / Volume:
70 
Heft / Issue:
Seitenangaben Beitrag:
390-3 
Sprache:
eng 
Print-ISSN:
2168-6149 
TUM Einrichtung:
Neurologische Klinik und Poliklinik