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Dokumenttyp:
journal article 
Autor(en):
Cravens, PD; Kieseier, BC; Hussain, R; Herndon, E; Arellano, B; Ben, LH; Timmons, BC; Castro-Rojas, C; Hartung, HP; Hemmer, B; Weber, MS; Zamvil, SS; Stüve, O 
Titel:
The neonatal CNS is not conducive for encephalitogenic Th1 T cells and B cells during experimental autoimmune encephalomyelitis. 
Abstract:
Multiple sclerosis (MS) is thought to be a CD4+ T cell mediated autoimmune demyelinating disease of the central nervous system (CNS) that is rarely diagnosed during infancy. Cellular and molecular mechanisms that confer disease resistance in this age group are unknown. We tested the hypothesis that a differential composition of immune cells within the CNS modulates age-associated susceptibility to CNS autoimmune disease. C57BL/6 mice younger than eight weeks were resistant to experimental autoim...    »
 
Zeitschriftentitel:
J Neuroinflammation 
Jahr:
2013 
Band / Volume:
10 
Seitenangaben Beitrag:
67 
Sprache:
eng 
TUM Einrichtung:
Neurologische Klinik und Poliklinik