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Dokumenttyp:
journal article 
Autor(en):
Neumann, Konstantin; Castiñeiras-Vilariño, Mercedes; Höckendorf, Ulrike; Hannesschläger, Nicole; Lemeer, Simone; Kupka, Danny; Meyermann, Svenia; Lech, Maciej; Anders, Hans-Joachim; Kuster, Bernhard; Busch, Dirk H; Gewies, Andreas; Naumann, Ronald; Groß, Olaf; Ruland, Jürgen 
Titel:
Clec12a Is an Inhibitory Receptor for Uric Acid Crystals that Regulates Inflammation in Response to Cell Death. 
Abstract:
Recognition of cell death by the innate immune system triggers inflammatory responses. However, how these reactions are regulated is not well understood. Here, we identify the inhibitory C-type lectin receptor Clec12a as a specific receptor for dead cells. Both human and mouse Clec12a could physically sense uric acid crystals (monosodium urate, MSU), which are key danger signals for cell-death-induced immunity. Clec12a inhibited inflammatory responses to MSU in vitro, and Clec12a-deficient mice...    »
 
Zeitschriftentitel:
Immunity 
Jahr:
2014 
Band / Volume:
40 
Heft / Issue:
Seitenangaben Beitrag:
389-99 
Sprache:
eng 
Print-ISSN:
1074-7613 
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene