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Document type:
journal article 
Author(s):
Schwartz, Christian; Oeser, Katharina; Prazeres da Costa, Clarissa; Layland, Laura E; Voehringer, David 
Title:
T cell-derived IL-4/IL-13 protects mice against fatal Schistosoma mansoni infection independently of basophils. 
Abstract:
Schistosomiasis is a severe and chronic disease caused by the parasitic trematode Schistosoma mansoni after deposition of eggs in the liver and intestines. The immune response to S. mansoni eggs is characterized by increased Th2 cells, eosinophilia, and high serum IgE levels. Granulomas are formed around the eggs to protect the organs against tissue damage caused by toxic products that are secreted from the eggs. Egg-derived components have further been shown to activate the IgE-mediated release...    »
 
Journal title abbreviation:
J Immunol 
Year:
2014 
Journal volume:
193 
Journal issue:
Pages contribution:
3590-9 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene