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Dokumenttyp:
journal article 
Autor(en):
Petzold, Tobias; Ruppert, Raphael; Pandey, Dharmendra; Barocke, Verena; Meyer, Hannelore; Lorenz, Michael; Zhang, Lin; Siess, Wolfgang; Massberg, Steffen; Moser, Markus 
Titel:
?1 integrin-mediated signals are required for platelet granule secretion and hemostasis in mouse. 
Abstract:
Integrins are critical for platelet adhesion and aggregation during arterial thrombosis and hemostasis. Although the platelet-specific ?IIb?3 integrin is known to be crucial for these processes, the in vivo role of ?1 integrins is a matter of debate. Here we demonstrate that mice expressing reduced levels of ?1 integrins or an activation-deficient ?1 integrin show strongly reduced platelet adhesion to collagen in vitro and in a carotis ligation model in vivo. Interestingly, hypomorphic mice expr...    »
 
Zeitschriftentitel:
Blood 
Jahr:
2013 
Band / Volume:
122 
Heft / Issue:
15 
Seitenangaben Beitrag:
2723-31 
Sprache:
eng 
Print-ISSN:
0006-4971 
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene