Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Kreslavsky, Taras; Kim, Hye-Jung; Koralov, Sergei B; Ghitza, Dvora; Buch, Thorsten; Cantor, Harvey; Rajewsky, Klaus; von Boehmer, Harald 
Titel:
Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes. 
Abstract:
Antigen receptor editing-a process of secondary rearrangements of antigen receptor genes in autoreactive lymphocytes-is a well-established tolerance mechanism in B cells, whereas its role in T cells remains controversial. Here, we investigated this issue using a novel Tcra knock-in locus, which ensured appropriate timing of TCR? expression and allowed secondary rearrangements. Under these conditions the only response to self-antigen that could be unambiguously identified was negative selection o...    »
 
Zeitschriftentitel:
J Exp Med 
Jahr:
2013 
Band / Volume:
210 
Heft / Issue:
10 
Seitenangaben Beitrag:
1911-8 
Sprache:
eng 
Print-ISSN:
0022-1007 
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene