Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Fejer, György; Wegner, Mareike Dorothee; Györy, Ildiko; Cohen, Idan; Engelhard, Peggy; Voronov, Elena; Manke, Thomas; Ruzsics, Zsolt; Dölken, Lars; Prazeres da Costa, Olivia; Branzk, Nora; Huber, Michael; Prasse, Antje; Schneider, Robert; Apte, Ron N; Galanos, Chris; Freudenberg, Marina A 
Titel:
Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions. 
Abstract:
Macrophages are diverse cell types in the first line of antimicrobial defense. Only a limited number of primary mouse models exist to study their function. Bone marrow-derived, macrophage-CSF-induced cells with a limited life span are the most common source. We report here a simple method yielding self-renewing, nontransformed, GM-CSF/signal transducer and activator of transcription 5-dependent macrophages (Max Planck Institute cells) from mouse fetal liver, which reflect the innate immune chara...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2013 
Band / Volume:
110 
Heft / Issue:
24 
Seitenangaben Beitrag:
E2191-8 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene