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Dokumenttyp:
journal article 
Autor(en):
Ju, L; Wing, J; Taylor, E; Brandt, R; Slijepcevic, P; Horsch, M; Rathkolb, B; Rácz, I; Becker, L; Hans, W; Adler, T; Beckers, J; Rozman, J; Klingenspor, M; Wolf, E; Zimmer, A; Klopstock, T; Busch, DH; Gailus-Durner, V; Fuchs, H; Angelis, MH; van der Horst, G; Lehmann, AR 
Titel:
SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities. 
Abstract:
Smc5-6 is a highly conserved protein complex related to cohesin and condensin involved in the structural maintenance of chromosomes. In yeasts the Smc5-6 complex is essential for proliferation and is involved in DNA repair and homologous recombination. siRNA depletion of genes involved in the Smc5-6 complex in cultured mammalian cells results in sensitivity to some DNA damaging agents. In order to gain further insight into its role in mammals we have generated mice mutated in the Smc6 gene. A co...    »
 
Zeitschriftentitel:
DNA Repair (Amst) 
Jahr:
2013 
Band / Volume:
12 
Heft / Issue:
Seitenangaben Beitrag:
356-66 
Sprache:
eng 
Print-ISSN:
1568-7864 
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene