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Document type:
journal article 
Author(s):
Desel, C; Werninghaus, K; Ritter, M; Jozefowski, K; Wenzel, J; Russkamp, N; Schleicher, U; Christensen, D; Wirtz, S; Kirschning, C; Agger, EM; da Costa, CP; Lang, R 
Title:
The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling. 
Abstract:
Successful vaccination against intracellular pathogens requires the generation of cellular immune responses. Trehalose-6,6-dibehenate (TDB), the synthetic analog of the mycobacterial cord factor trehalose-6,6-dimycolate (TDM), is a potent adjuvant inducing strong Th1 and Th17 immune responses. We previously identified the C-type lectin Mincle as receptor for these glycolipids that triggers the FcR?-Syk-Card9 pathway for APC activation and adjuvanticity. Interestingly, in vivo data revealed that...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2013 
Journal volume:
Journal issue:
Pages contribution:
e53531 
Language:
eng 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene