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Document type:
journal article 
Author(s):
Hacker, Charlotte; Verbeek, Mareike; Schneider, Heike; Steimer, Werner 
Title:
Falsely elevated cyclosporin and tacrolimus concentrations over prolonged periods of time due to reversible adsorption to central venous catheters. 
Abstract:
Falsely elevated concentrations of immunosuppressants can be caused by reversible adsorption to central venous catheter (CVC) systems. If undetected, this may lead to dose reduction resulting in underdosage which may even entail graft-versus-host disease or organ rejection. We analyzed the adsorption and release for cyclosporine A (CsA) and tacrolimus (Tac) in vitro and in vivo. Four types of CVCs were examined in vitro: two made from polyurethane (PU), one from silicone and one from PU with an...    »
 
Journal title abbreviation:
Clin Chim Acta 
Year:
2014 
Journal volume:
433 
Pages contribution:
62-8 
Language:
eng 
Print-ISSN:
0009-8981 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; III. Medizinische Klinik und Poliklinik