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Dokumenttyp:
journal article 
Autor(en):
Lang, PA; Shaabani, N; Borkens, S; Honke, N; Scheu, S; Booth, S; Brenner, D; Meryk, A; Barthuber, C; Recher, M; Mak, TW; Ohashi, PS; Häussinger, D; Griffiths, GM; Thrasher, AJ; Bouma, G; Lang, KS 
Titel:
Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency. 
Abstract:
Wiskott-Aldrich syndrome (WAS) is a rare X-linked primary immunodeficiency caused by absence of Wiskott-Aldrich syndrome protein (WASP) expression, resulting in defective function of many immune cell lineages and susceptibility to severe bacterial, viral, and fungal infections. Despite a significant proportion of patients with WAS having recurrent viral infections, surprisingly little is known about the effects of WASP deficiency on antiviral immunity.We sought to evaluate the antiviral immune r...    »
 
Zeitschriftentitel:
J Allergy Clin Immunol 
Jahr:
2013 
Band / Volume:
131 
Heft / Issue:
Seitenangaben Beitrag:
815-824.e2 
Sprache:
eng 
Print-ISSN:
0091-6749 
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie