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Dokumenttyp:
journal article 
Autor(en):
Damgaard, Rune Busk; Fiil, Berthe Katrine; Speckmann, Carsten; Yabal, Monica; zur Stadt, Udo; Bekker-Jensen, Simon; Jost, Philipp J; Ehl, Stephan; Mailand, Niels; Gyrd-Hansen, Mads 
Titel:
Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling. 
Abstract:
X-linked Inhibitor of Apoptosis (XIAP) is an essential ubiquitin ligase for pro-inflammatory signalling downstream of the nucleotide-binding oligomerization domain containing (NOD)-1 and -2 pattern recognition receptors. Mutations in XIAP cause X-linked lymphoproliferative syndrome type-2 (XLP2), an immunodeficiency associated with a potentially fatal deregulation of the immune system, whose aetiology is not well understood. Here, we identify the XIAP baculovirus IAP repeat (BIR)2 domain as a ho...    »
 
Zeitschriftentitel:
EMBO Mol Med 
Jahr:
2013 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
1278-95 
Sprache:
eng 
Print-ISSN:
1757-4676 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik