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Document type:
journal article 
Author(s):
Dörr, JR; Yu, Y; Milanovic, M; Beuster, G; Zasada, C; Däbritz, JH; Lisec, J; Lenze, D; Gerhardt, A; Schleicher, K; Kratzat, S; Purfürst, B; Walenta, S; Mueller-Klieser, W; Gräler, M; Hummel, M; Keller, U; Buck, AK; Dörken, B; Willmitzer, L; Reimann, M; Kempa, S; Lee, S; Schmitt, CA 
Title:
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. 
Abstract:
Activated oncogenes and anticancer chemotherapy induce cellular senescence, a terminal growth arrest of viable cells characterized by S-phase entry-blocking histone 3 lysine 9 trimethylation (H3K9me3). Although therapy-induced senescence (TIS) improves long-term outcomes, potentially harmful properties of senescent tumour cells make their quantitative elimination a therapeutic priority. Here we use the Eµ-myc transgenic mouse lymphoma model in which TIS depends on the H3K9 histone methyltransfer...    »
 
Journal title abbreviation:
Nature 
Year:
2013 
Journal volume:
501 
Journal issue:
7467 
Pages contribution:
421-5 
Language:
eng 
Print-ISSN:
0028-0836 
TUM Institution:
III. Medizinische Klinik und Poliklinik; Nuklearmedizinische Klinik und Poliklinik