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Dokumenttyp:
journal article 
Autor(en):
Gasparitsch, M; Arndt, AK; Pawlitschek, F; Oberle, S; Keller, U; Kasper, M; Bierhaus, A; Schaefer, F; Weber, LT; Lange-Sperandio, B 
Titel:
RAGE-mediated interstitial fibrosis in neonatal obstructive nephropathy is independent of NF-?B activation. 
Abstract:
Urinary tract obstruction during nephron development causes tubular apoptosis, tubular atrophy, and interstitial fibrosis. Leukocyte recruitment is critical in the development of obstructive nephropathy leading to interstitial inflammation and renal fibrosis. RAGE, the receptor of advanced glycation end products, is implicated in chronic inflammation and has been recently identified as a novel receptor for the ?2-integrin Mac-1, cooperating with ICAM-1 and thereby directly mediating leukocyte re...    »
 
Zeitschriftentitel:
Kidney Int 
Jahr:
2013 
Band / Volume:
84 
Heft / Issue:
Seitenangaben Beitrag:
911-9 
Sprache:
eng 
Print-ISSN:
0085-2538 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik