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Dokumenttyp:
journal article 
Autor(en):
Lutzny, G; Kocher, T; Schmidt-Supprian, M; Rudelius, M; Klein-Hitpass, L; Finch, AJ; Dürig, J; Wagner, M; Haferlach, C; Kohlmann, A; Schnittger, S; Seifert, M; Wanninger, S; Zaborsky, N; Oostendorp, R; Ruland, J; Leitges, M; Kuhnt, T; Schäfer, Y; Lampl, B; Peschel, C; Egle, A; Ringshausen, I 
Titel:
Protein Kinase C-?-Dependent Activation of NF-?B in Stromal Cells Is Indispensable for the Survival of Chronic Lymphocytic Leukemia B Cells In Vivo. 
Abstract:
Tumor cell survival critically depends on heterotypic communication with benign cells in the microenvironment. Here, we describe a survival signaling pathway activated in stromal cells by contact to B cells from patients with chronic lymphocytic leukemia (CLL). The expression of protein kinase C (PKC)-?II and the subsequent activation of NF-?B in bone marrow stromal cells are prerequisites to support the survival of malignant B cells. PKC-? knockout mice are insusceptible to CLL transplantations...    »
 
Zeitschriftentitel:
Cancer Cell 
Jahr:
2013 
Band / Volume:
23 
Heft / Issue:
Seitenangaben Beitrag:
77-92 
Sprache:
eng 
Print-ISSN:
1535-6108 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik; Institut für Allgemeine Pathologie und pathologische Anatomie; Institut für Klinische Chemie und Pathobiochemie