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Dokumenttyp:
journal article 
Autor(en):
Shibata, Wataru; Ariyama, Hiroshi; Westphalen, Christoph Benedikt; Worthley, Daniel L; Muthupalani, Sureshkumar; Asfaha, Samuel; Dubeykovskaya, Zinaida; Quante, Michael; Fox, James G; Wang, Timothy C 
Titel:
Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors. 
Abstract:
Stromal cell-derived factor-1 (SDF-1/CXCL12), the main ligand for CXCR4, is overexpressed in human cancer. This study addressed the precise contribution of SDF-1 to gastric carcinogenesis.SDF-1 transgenic mice were created and a Helicobacter-induced gastric cancer model was used in combination with H/K-ATPase-IL-1? mice. Gastric tissue was analysed by histopathology and cells isolated from the stomach were analysed by molecular biological methods.Analysis of the H/K-ATPase/SDF-1 transgenic (SDF-...    »
 
Zeitschriftentitel:
Gut 
Jahr:
2013 
Band / Volume:
62 
Heft / Issue:
Seitenangaben Beitrag:
192-200 
Sprache:
eng 
Print-ISSN:
0017-5749 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik